The liver is vulnerable to alcohol-related injury because it is the primary site of alcohol metabolism. Additionally, a number of potentially dangerous\udby-products are generated as alcohol is broken down in the liver. However, dietary supplements may prevent or relieve some of alcohol’s deleterious\udeffects. Therefore, this study was conducted to evaluate the prophylactic effect of aqueous extract of Sesamum indicum (SI) on ethanol induced\udtoxicity in rats. Male Wistar albino rats were divided into control, ethanol, pre-treatment, simultaneous and post-treatment groups. In the prophylactic\udexperiment, Sesamum indicum, (200 mg/kg body weight) was administered by oral gavage for 28 days; two hours before, simultaneously with or\udtwo hours after ethanol exposure. Toxicity was induced by administering 45% ethanol (4.8 g/kg bw) by oral gavage. Lipid peroxidation (TBARS)\udand reduced glutathione (GSH) levels and catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) and gluthathione-S-transferase\ud(GST) activities were then determined in the liver, serum triglyceride (TG) levels, alanine aminotransferase (ALT) and aspartate aminotransferase\ud(AST) activities were monitored and histological examination was carried out. The results revealed that ethanol administration led to significant\udelevation of TBARS level while depleting in the level of GSH as well as CAT, GPx, SOD and GST activities. Similarly, TG level and ALT and\udAST activities were elevated. The SI pre-treated group significantly inhibited TBARS, restored GSH level, enhanced CAT, GPx, SOD and GST\udactivities and significantly decreased the elevated level of serum TG, ALT and AST activities. SI treatment (simultaneously with ethanol) exhibited\udsimilar effects to those of the SI pre-treated groups, while the SI post-treated group did not show the same protection as the Pre-treated group.\udS. indicum possesses antioxidant and hepatoprotective properties, that eliminate the deleterious effects of toxic metabolites of ethanol.
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机译：肝脏很容易遭受酒精引起的伤害，因为它是酒精代谢的主要部位。此外，随着酒精在肝脏中分解，还会产生许多潜在的危险\副产品。但是，膳食补充剂可能会预防或缓解某些酒精的有害\不良影响。因此，本研究旨在评估印度芝麻（SI）的水提液对大鼠乙醇诱导的毒性的预防作用。将雄性Wistar白化病大鼠分为对照组，乙醇，治疗前，同时和治疗后组。在预防/实验中，通过口服管饲法对印度芝麻（Sesamum indicum）（200 mg / kg体重）进行给药，持续28天。乙醇暴露前两个小时，或同时或之后两个小时。通过口服管饲法施用45％的乙醇（4.8 g / kg bw）诱导毒性。然后测定肝脏，血清中脂质过氧化（TBARS）\ ud和降低的谷胱甘肽（GSH）水平和过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GPx），超氧化物歧化酶（SOD）和谷胱甘肽S-转移酶\ ud（GST）活性监测甘油三酸酯（TG）水平，丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶\ ud（AST）的活性并进行组织学检查。结果表明，乙醇施用导致TBARS水平显着降低，而GSH以及CAT，GPx，SOD和GST活性则降低。同样，TG水平，ALT和\ udAST活性也升高。 SI预处理组显着抑制TBARS，恢复GSH水平，增强CAT，GPx，SOD和GST \活性，并显着降低血清TG，ALT和AST活性升高。 SI处理（同时用乙醇）显示出与SI预处理组相似的效果，而SI后处理组未显示出与预处理组相同的保护作用。 Indicum具有抗氧化和保肝作用，可消除乙醇有毒代谢产物的有害影响。
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